Tetrabutylammonium Fluoride → HCID 18665560, compound

Participants

Reaction Steps

To a solution of 2-(3-tert-butyldimethylsilyloxy-2-fluorophenyl)-4,5-dihydro-5(R)-phenyloxazole (2.2 g, 5.8 mmol) in THF (20 ml) was added dropwise tetrabutylammonium fluoride (1M in THF, 7 ml). The reaction mixture was stirred at ambient temperature for 10 min., volatiles removed by evaporation and the resulting residue was purified by column chromatography on silica gel eluting with hexane-ethyl acetate (3:2) to afford the title compound (1.3 g, 86%) as colorless solids.

Provenance & Evidence