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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2395403Generated: October 25, 2026

Rolipram → 1-(6-Fluoroquinolin-2-ylmethyl)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone

https://huagongshe.com/reaction/2395403

Reaction equation

Participants

RoleNameHCIDCharge
ReactantRolipramHCID 5092—
Reactant2-(Chloromethyl)-6-fluoroquinolineHCID 11241007—
Product1-(6-Fluoroquinolin-2-ylmethyl)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinoneHCID 18971748—

Reaction Steps

Reaction of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone with 2-chloromethyl-6-fluoroquinoline, analogous to the procedure of Example 29, yielded the title compound. M.P.: 65°-68° C. High Resolution Mass Spectra: Calc'd: 434.1983. Found: 434.2005.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05814651
Source datasetuspto-grants-1998_09
ORD IDord-dcc912890d2a40a783f98d42569334ef
Source noteuspto-grants-1998_09