Cyclopropylamine → HCID 57989629, compound

HRID 239553Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])=[N:10][C:9]=2[C:17]2[C:18]([F:35])=[C:19]([NH:23][S:24]([C:27]3[C:32]([F:33])=[CH:31][CH:30]=[CH:29][C:28]=3[F:34])(=[O:26])=[O:25])[CH:20]=[CH:21][CH:22]=2)[CH:5]=[CH:4][N:3]=1.[CH:36]1([NH2:39])[CH2:38][CH2:37]1>>[CH:36]1([NH:39][C:2]2[N:7]=[C:6]([C:8]3[S:12][C:11]([C:13]([CH3:15])([CH3:16])[CH3:14])=[N:10][C:9]=3[C:17]3[C:18]([F:35])=[C:19]([NH:23][S:24]([C:27]4[C:28]([F:34])=[CH:29][CH:30]=[CH:31][C:32]=4[F:33])(=[O:26])=[O:25])[CH:20]=[CH:21][CH:22]=3)[CH:5]=[CH:4][N:3]=2)[CH2:38][CH2:37]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 57989782N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl)-2-fluoraphenyl)-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989629HCID 57989629, compound

Procedure

Following a procedure analogous to the procedure described in Example 290 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide (250 mg, 0.464 mmol) and cyclopropylamine (0.163 mL, 2.31 mmol), the title compound was obtained as a white solid (40 mg, 14%). MS (ESI): 560 [M+H]+.

Sources & evidence

ORD record: ord-c584d1acd85c413da3c2983b1790e870
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642759B2

Reaction notes

Loading…