Triethylamine → HCID 10513072, compound

Participants

Reaction Steps

A mixture of the methyl ester of 3-(cyanomethoxy)benzo[b]thiophene-2-carboxylic acid (405 mg, 1.64 mmols) [J. Hetero. Chem., 12:1037 (1975)], 0.5 mL of Et3N and 0.50 g of RaCo in 50 mL of THF is heated at 100° C. under 1200 psi of hydrogen. The reaction mixture is concentrated in vacuo. Column chromatography eluting with a gradient of 1:1 hexane:ethyl acetate to all ethyl acetate provides 2,3-dihydro -[1]benzothieno[2,3-f]1,4-oxazepin-5(4H)-one in 55% yield; mp 244°-245° C.

Provenance & Evidence