HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Fluoro-1,3-benzoxazol-2-one-7-carboxylic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Fluoro-2-oxo-2,3-dihydro-1,3-benzoxazole-7-carboxylic acid | HCID 14690686 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Fluoro-1,3-benzoxazol-2-one-7-carboxylic acid chloride | HCID 53757117 | — |
Reaction Steps
A stirred suspension of 4-fluoro-1,3-benzoxazol-2-one-7-carboxylic acid (1.79 g) in dry dichloromethane was treated with oxalyl chloride (0.97 g), followed by N,N-dimethylformamide (3 drops) to initiate the reaction. Stirring was maintained under reflux conditions for 1.5 hours and the mixture evaporated to dryness to give 4-fluoro-1,3-benzoxazol-2-one-7-carboxylic acid chloride, used in the next stage without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489570 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-aad537e1d627445ca49652c8d898657a |
| Source note | uspto-grants-1996_02 |