Water → HCID 18989204, compound

Participants

Reaction Steps

A mixture of methyl 4-chloro-3-methoxybenzo[b]thiophene-5-carboxylate (8.35 g) and lithium hydroxide hydrate (1.37 g) was stirred in methanol (75 ml) and water (25 ml) at room temperature for 4 days. The methanol was evaporated in vacuo and the mixture poured onto excess cold dilute hydrochloric acid. The solid was filtered, washed with cold cyclohexane and dried to give 4-chloro-3-methoxybenzo[b]thiophene-5-carboxylic acid (7.28 g) as a white solid, NMR (d6DMSO) δ3.9(3H,s), 7.0(1H,s), 7.6(1H,d), 7.95(1H,d), 13.3(1H,brs).

Provenance & Evidence