Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | HCID 18989442 | HCID 18989442 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 18989443 | HCID 18989443 | — |
Reaction Steps
A solution of 4.2 g (0.0182 mol) of (E)-3-(3-bromo-5-fluorophenyl)-2-propen-1-ol in 65 ml of anhydrous ether is cooled to 0° C. under a nitrogen atmosphere. 3.3 g (0.0121 mol) of phosphorus tribromide are added dropwise and then the mixture is stirred for 1 h at 0° C. and left to return to room temperature overnight. The mixture is poured into water and extraction with ether, washing with water, drying over sodium sulphate, filtration and concentration under vacuum are carried out.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05489592 |
|---|
| Source dataset | uspto-grants-1996_02 |
|---|
| ORD ID | ord-fee933fb32a54274abb250dada81bc63 |
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| Source note | uspto-grants-1996_02 |
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