反应详情

The 3-(4-bromo-2-fluorophenyl)-2-propenoic acid obtained (17.1 g, 0.0698 mol) is taken up in 250 ml of methanol and 0.5 ml of concentrated sulphuric acid and heated for 12 h at reflux. Evaporation is carried out under vacuum and the residue purified by chromatography on silica (eluent: 1/1 hexane/ethyl acetate). Yd.: 14.7 g (81%) M.p. : 63°-65° C.

1. temperatureat reflux
2. customEvaporation
3. customthe residue purified by chromatography on silica (eluent: 1/1 hexane/ethyl acetate)
4. custom63°-65° C.