Hydrochloric Acid → HCID 53839942, compound

Participants

Reaction Steps

A mixture of 5.1 g (0.02 mol) of 1,3-dibromo-5- fluorobenzene (prepared according to A. Cannoni de Degiorgi and E. V. Zappi, Anales asoc. quim. argentina, 1940, 28, 72) (C. A. 34 65933), 2.2 ml (0.025 mol) of methyl acrylate, 10 ml of triethylamine, 0.044 g (0.002 mol) of palladium acetate and 0.208 g (0.0008 mol) of triphenylphosphine is heated for 24 h at 100° C. in a closed vessel with magnetic stirring. Cooling, pouring into 1N HCl, extraction with ether, washing with water, drying over Na2SO4, filtration and evaporation under vacuum are carried out. The residue is purified by chromatography on silica (eluent: 2/1 hexane/ethyl acetate). Yd.: 2.7 g (51%) M.p.=95°-6° C.

Provenance & Evidence