HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-N-methyl-3-pyridinemethanamine → N-(2-chloropyrid-5-ylmethyl)-N-methyl-N'-nitroguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-N-methyl-3-pyridinemethanamine | HCID 11094883 | — |
| Reactant | N-Nitro-S-methylisothiourea | HCID 135927615 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(2-chloropyrid-5-ylmethyl)-N-methyl-N'-nitroguanidine | HCID 53959606 | 31.2% |
Reaction Steps
A mixture of 0.676 g of S-methyl-N-nitroisothiourea, 0.783 g of 2-chloro-5-(methylaminomethyl)pyridine and 6 ml of acetonitrile was refluxed for 17 hours, and concentrated. The residue was recrystallized from ethanol to obtain 0.38 g of 1-(6-chloro-3-pyridylmethyl)-1-methyl-2-nitroguanidine (Compound No. 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489603 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-13e9e9b98ff74cadb2a0ef7fc8385380 |
| Source note | uspto-grants-1996_02 |