Hydrochloric Acid → HCID 86749241, compound

Participants

Reaction Steps

A mixture of 2-bromo-3-[2-[2-(5-methyl-2-phenyl-4-thiazolyl)ethoxy]-5-pyridyl]propionic acid methyl ester (1.40 g), thiourea (0.25 g) and ethanol (20 ml) was heated for 4.5 hours while refluxing, followed by addition of 2N hydrochloric acid (20 ml) and heating for 18 more hours under refluxing conditions. The reaction mixture was added to water and extracted with dichloromethane. After the dichloromethane layer was washed with water and dried (MgSO4), the solvent was distilled off. The residual crystal was recrystallized from ethanol-chloroform to yield 5-[[2-[2-(5-methyl-2-phenyl-4-thiazolyl)ethoxy]-5-pyridyl]methyl]-2,4-thiazolidinedione (0.66 g, 51%) as a colorless crystal.

Provenance & Evidence