HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 5-[[2-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]methylidene]-2,4-thiazolidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde | HCID 18546151 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-[[2-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]methylidene]-2,4-thiazolidinedione | HCID 53910517 | 29.3% |
Reaction Steps
A mixture of 5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl) ethoxy]pyridine (0.6 g), 2,4-thiazolidinedione (0.235 g), piperidine (0.066 ml) and ethanol (20 ml) was heated for 9 hours while refluxing. The reaction mixture was poured into water; the separating crystal, collected by filtration, was then recrystallized from ethanol-chloroform to yield 5-[[2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]methylidene]-2,4-thiazolidinedione (0.232 g, 29%) as a yellow crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489602 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-77c5322584f14d579e245f3b09231f43 |
| Source note | uspto-grants-1996_02 |