1,4-Dioxane → 5,6,7,13-Tetrahydro-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanoic acid

Participants

Reaction Steps

147 mg (0.33 mmole) 12-(2-tert.-butoxycarbonylethyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole are stirred for 16 hours at 20° C. in 5 mL 18% hydrochloric acid and 5 mL dioxan and then for 2 hours at 50° C. The product formed is filtered off, washed with a little water and ethanol and dried in a vacuum at 90° C. 12-(2-Carboxyethyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole is obtained in the form of pale beige crystals which decompose above 320° C.

Provenance & Evidence