HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-4-(2-nitrophenyl)piperazine → tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-4-(2-nitrophenyl)piperazine | HCID 21935210 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate | HCID 2795530 | — |
Reaction Steps
1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (PREPARATION 12, 7.61 g) is dissolved in ethanol (150 ml). Palladium on carbon (10%, 0.75 g) is added and the reaction is hydrogenated at 45 psi for 6 hr. The mixture is filtered thru celite and concentrated under reduced pressure to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489593 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-dcc8180b8f254375961bdb1b339ffe00 |
| Source note | uspto-grants-1996_02 |