反应详情

A solution of ethyl 5-methoxy-4,5,7 trimethylindole-2-carboxylate (PREPARATION 19, 1.04 g) in ethanol (30 ml) containing potassium hydroxide (45%, 2.5 ml) is heated under reflux for 1.5 hr. The mixture is acidified with acetic acid (2 ml) and concentrated under reduced pressure. The residue is mixed with water (200 ml) and filtered. The filter cake is washed with water and dried to give the title compound.

1. temperatureis heated
2. temperatureunder reflux for 1.5 hr
3. concentrationconcentrated under reduced pressure
4. additionThe residue is mixed with water (200 ml)
5. filtrationfiltered
6. washThe filter cake is washed with water
7. customdried