Potassium Hydroxide → 5-bromo-6-methoxy-1H-indole-2-carboxylic acid

HRID 2395769Notes

Reaction equation

HRID 2395769 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([O:15]C)=[O:14])=[CH:5]2.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([OH:15])=[O:14])=[CH:5]2

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 16726758methyl 5-bromo-6-methoxy-1H-indole-2-carboxylate

Product 1

HCID 194188695-bromo-6-methoxy-1H-indole-2-carboxylic acid

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5-bromo-6-methoxyindole carboxylate (PREPARATION 81, 3.31 g) and potassium hydroxide (0.98 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.79, 7.03, 7.01 and 3.89 δ.

Workup

  1. customthe general procedure of PREPARATION 63

Sources & evidence

ORD record
ord-a5e183ffc1aa497a846807de9d038e6d
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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