Potassium Hydroxide → 4-Methyl-1H-indole-2-carboxylic acid

HRID 2395772Notes

Reaction equation

HRID 2395772 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13]C)=[O:12])[NH:6]2.[OH-].[K+]>>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([OH:13])=[O:12])[NH:6]2

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 4714967methyl 4-methyl-1H-indole-2-carboxylate

Product 1

HCID 39260874-Methyl-1H-indole-2-carboxylic acid

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 4-methylindole-2-carboxylate (PREPARATION 85, 4.94 g), potassium hydroxide (1.75 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.24, 7.19, 7.12, 6.85 and 2.51 δ.

Workup

  1. customthe general procedure of PREPARATION 63

Sources & evidence

ORD record
ord-71945745ce3747f09a9f5cee55c29301
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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