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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2395797Generated: October 30, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[5-Fluoro-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine

https://huagongshe.com/reaction/2395797

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
Reactant3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-HCID 10013750—
Reactant5-Fluoro-6-methoxy-1h-indole-2-carboxylic acidHCID 19418795—
Product1-[5-Fluoro-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazineHCID 489450—

Reaction Steps

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 5-fluoro-6-methoxyindole-2-carboxylic acid (PREPARATION 92, 0.30 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.32 g) and 1-(ethyl)-3-(dimethylaminopropyl) carbodiimide (0.33 g), the title compound is obtained, mp 193°-194°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05489593
Source datasetuspto-grants-1996_02
ORD IDord-bad0a171698640dbbba18338038ea323
Source noteuspto-grants-1996_02