HCID 11029443, compound → Ioversol

HRID 2395870Notes

Reaction equation

C([O:4][CH2:5][C:6]([NH:8][C:9]1[C:10]([I:45])=[C:11]([C:31]([NH:33][CH2:34][CH:35]([O:41]C(=O)C)[CH2:36][O:37]C(=O)C)=[O:32])[C:12]([I:30])=[C:13]([C:28]=1[I:29])[C:14]([NH:16][CH2:17][CH:18]([O:24]C(=O)C)[CH2:19][O:20]C(=O)C)=[O:15])=[O:7])(=O)C.[C:46](OCCCC(ON(C1C(I)=C(C(N)=O)C(I)=C(C=1I)C(N(CC(OC(=O)C)COC(=O)C)CC(OC(=O)C)COC(=O)C)=O)C(=O)C)=O)(=[O:48])[CH3:47]>>[CH2:47]([N:8]([C:6]([CH2:5][OH:4])=[O:7])[C:9]1[C:28]([I:29])=[C:13]([C:14]([NH:16][CH2:17][CH:18]([OH:24])[CH2:19][OH:20])=[O:15])[C:12]([I:30])=[C:11]([C:31]([NH:33][CH2:34][CH:35]([OH:41])[CH2:36][OH:37])=[O:32])[C:10]=1[I:45])[CH2:46][OH:48].[OH:24][CH:18]([CH2:19][OH:20])[CH2:17][NH:16][C:14](=[O:15])[C:13]1[C:28]([I:29])=[C:9]([NH:8][C:6](=[O:7])[CH2:5][OH:4])[C:10]([I:45])=[C:11]([C:31]([NH:33][CH2:34][CH:35]([OH:41])[CH2:36][OH:37])=[O:32])[C:12]=1[I:30]

Participants

Reactant 2

HCID 11029443HCID 11029443, compound

HCID 86749244HCID 86749244, compound

Product 2

HCID 3741Ioversol

HCID 10908853AG-H-12138

Procedure

) acid hydrolyzing said 5-acetoxyacetamido-N,N'-bis(2,3-diacetoxypropyl)2,4,6-triiodoisophthalamide and 5-[N-(2-acetoxyethyl)acetoxyacetamido]-N,N-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide under acid hydrolyzing conditions to produce ioversol and N,N'-bis-(2,3-dihydroxypropyl)-5-glycolamido-2,4,6-triiodoisophthalamide; and

Sources & evidence

ORD record: ord-d855f82d74824458a187750a693b2b1d
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05489708

Reaction notes

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