反应详情

100 ml of 2-chlorobenzotrifluoride and 4.5 g of potassium chloride were placed at 110° C. in a chlorination apparatus with UV irradiation and 50 g of 3-chloro-2,4,5-trifluorobenzaldehyde in 50 ml of 2-chlorobenzotrifluoride were subsequently added dropwise with exclusion of air. After addition of 10 ml of the solution, chlorine was added at the rate at which it was absorbed. The metered addition was continued until the entire amount of the aldehyde used had reacted (gas chromatographic monitoring). Distillation of the reaction mixture gave 52 g of 3-chloro-2,4,5-trifluorobenzoyl chloride having a boiling point of 92° C./20 mbar.

1. additionwere subsequently added dropwise with exclusion of air
2. additionwas added at the rate at which it
3. customwas absorbed
4. additionThe metered addition
5. customused had reacted (gas chromatographic monitoring)
6. distillationDistillation of the reaction mixture