Ethanolamine → HCID 54468234, compound

HRID 2395939Notes

Reaction equation

HRID 2395939 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][CH2:10][O:11][N:12]2C(=O)C3=CC=CC=C3C2=O)=[CH:4][CH:3]=1.C(CN)O>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[CH:9][CH2:10][O:11][NH2:12])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 54486942HCID 54486942, compound

Product 1

HCID 54468234HCID 54468234, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
30 °C

Procedure

33.4 g (0.093 mol) of N-[3-(4-bromophenyl)-prop-2-enyloxy]-phthalimide wereintroduced a little at a time into 50 ml of ethanolamine and the temperature increased to 30° C. during this procedure. The mixture was stirred for two hours at 60° C. and then allowed to cool, and 200 ml of dichloromethane were added. The mixture was extracted by shakingwith ice water. After drying was evaporating down the organic phase, the residue was recrystallized from petroleum ether. Yield: 95.3%; mp.: 35°-38° C.

Workup

  1. temperatureto cool
  2. extractionThe mixture was extracted
  3. customAfter drying
  4. customwas evaporating down the organic phase
  5. customthe residue was recrystallized from petroleum ether

Sources & evidence

ORD record
ord-952411edba40452cbd9dfbb28685eaa8
Source dataset
uspto-grants-1996_02
Patent number
US05491123

Reaction notes

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