HCID 18987993, compound → HCID 136006919, compound

Participants

Reaction Steps

2.7 g (15 mmol) of 4-(4-fluorophenyl)-but-3-ynoxyamine were added to a solution of 4 g (15 mmol) of 2-butyryl-3-hydroxy-5-tetrahydropyran-4-ylcyclohex-2-enone in 60 ml of drymethanol. The mixture was stirred for 16 hours at room temperature, after which the methanol was removed under reduced pressure from a water pump. The crude product was purified by chromatography over silica gel (mobile phase: methylene chloride). Yield: 81.2%.

Provenance & Evidence