4-Hydroxy-3,3-dimethyl-1-butanesulfonamide → 6-(2,2-Dimethyl-4-sulfamoyl-1-butoxy)-7-methylimidazo[1,2-b]pyridazine

HRID 2395964Notes

Reaction equation

HRID 2395964 reaction equation
Cl[C:2]1[C:3]([CH3:11])=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[OH:12][CH2:13][C:14]([CH3:22])([CH3:21])[CH2:15][CH2:16][S:17]([NH2:20])(=[O:19])=[O:18]>>[CH3:21][C:14]([CH3:22])([CH2:15][CH2:16][S:17](=[O:19])(=[O:18])[NH2:20])[CH2:13][O:12][C:2]1[C:3]([CH3:11])=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1

Participants

3

Reactant 2

HCID 107499174-Hydroxy-3,3-dimethyl-1-butanesulfonamideHCID 122483366-Chloro-7-methylimidazo[1,2-b]pyridazine

Product 1

HCID 189881176-(2,2-Dimethyl-4-sulfamoyl-1-butoxy)-7-methylimidazo[1,2-b]pyridazineYield 26.2%

Procedure

Using 0.84 g of 6-chloro-7-methylimidazo[1,2-b]pyridazine and 0.91 g of 4-hydroxy-3,3-dimethyl-1-butanesulfonamide, 0.41 g of title compound was obtained in the same manner as in Example 3.

Sources & evidence

ORD record
ord-92ded07b7bee472aacbf94fa82c3d1c2
Source dataset
uspto-grants-1996_02
Patent number
US05491145

Reaction notes

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