HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Hexenoic acid, 2-[(phenylmethylene)amino]-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Methyl [(phenylmethylidene)amino]acetate | HCID 4169153 | — |
| Product | 5-Hexenoic acid, 2-[(phenylmethylene)amino]-, methyl ester | HCID 12039461 | — |
Reaction Steps
In step a, the N-(phenylmethylene)glycine methyl ester of structure 55 can be treated with one equivalent of a non-nucleophilic base, such as lithiumdiisopropylamide, in a suitable aprotic solvent, such as tetrahydrofuran, followed by addition of a 4-halobutene of structure 56 to give 2-(3-butenyl)-N-(phenylmethylene)glycine methyl ester of structure 57.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05491143 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-bcbc13e6d5b746c9a1bb3a9632be3e4c |
| Source note | uspto-grants-1996_02 |