Formamide → 4,5-Dianilinophthalimide

Participants

Reaction Steps

A suspension of 21.9 g (66.3 mmol) of 4,5-bis(anilino)phthalic anhydride in60 ml of formamide under argon atmosphere is heated at 125°-130° for 5 hours. The reaction mixture is cooled to 70°, and 250 ml of water are slowly added. This mixture is cooled to 0° for 30 minutes, and the reddish crystals are filtered off, washed with water and dried. Recrystallization from DMF/water yields the title compound in the form of orange crystals, m.p. 205°-207° C., FAB-MS: 330 [M+ +H].

Provenance & Evidence