HCID 53758475, compound → 4-Hydroxytoremifene

Participants

Reaction Steps

8.4 g of 4-chloro-1-(4-benzyloxyphenyl)-1-[4-[2-(N,N-dimethylamino )-ethoxy]phenyl]-2-phenyl-1-butene is hydrogenated in 340 ml of ethanol-ethyl acetate (1: 1) containing 11 drops of triethylamine using 5%Pd--C as a catalyst. The catalyst is filtered off and the solvent is evaporated. The residue is treated with ethanol and the product is filtered. The yield is 4.9 g (71%).

Provenance & Evidence