HCID 22858687, compound → HCID 22858688, compound

Participants

Reaction Steps

To a solution of N-[N-[2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl]-N-methylaminocarbonyl]-L-phenylalanine benzyl ester (1.50 g) in methanol (30 ml) was added in 1N sodium hydroxide aqueous solution (6 ml) at ambient temperature. After being stirred for 3 hours at the same temperature, the solution was concentrated in vacuo. The residue was dissolved in ethyl acetate (50 ml) and the solution was washed with 5% hydrochloric acid and brine successively, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give N-[N-[2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl]-N-methylaminocarbonyl]-L-phenylalanine (1.14 g) as an oil. Rf : 0.31 ( chloroform:methanol:acetic acid, 16:1:1, V/V)

Provenance & Evidence