Pravastatin Diol Lactone Di-(tert-butyldimethylsilyl) Ether → HCID 67675516, compound
Reaction equation
[CH2:1]([C:3]1[CH:15]=[CH:14][C:6]([O:7][CH:8]([CH2:12][CH3:13])[C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)[CH3:2].[Si:16]([O:23][C@H:24]1[CH2:33][C@H:32](O)[C@H:31]2[C:26]([CH:27]=[CH:28][C@H:29]([CH3:52])[C@@H:30]2[CH2:35][CH2:36][C@H:37]2[O:42][C:41](=[O:43])[CH2:40][C@H:39]([O:44][Si:45]([C:48]([CH3:51])([CH3:50])[CH3:49])([CH3:47])[CH3:46])[CH2:38]2)=[CH:25]1)([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17]>>[Si:16]([O:23][C@H:24]1[CH2:33][C@H:32]([O:10][C:9](=[O:11])[CH:8]([O:7][C:6]2[CH:14]=[CH:15][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=2)[CH2:12][CH3:13])[C@H:31]2[C:26]([CH:27]=[CH:28][C@H:29]([CH3:52])[C@@H:30]2[CH2:35][CH2:36][C@H:37]2[O:42][C:41](=[O:43])[CH2:40][C@H:39]([O:44][Si:45]([C:48]([CH3:51])([CH3:50])[CH3:49])([CH3:46])[CH3:47])[CH2:38]2)=[CH:25]1)([C:19]([CH3:20])([CH3:21])[CH3:22])([CH3:18])[CH3:17]Participants
3
Procedure
A procedure similar to that described in Example 1, above, was followed, but using 416 mg of (2RS)-2-(4-ethylphenoxy)butyric acid and 551 mg of (4R,6R)-6-{(1S,2S,6S,8S,8aR)-2-[1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl)tetrahydro-4-t-butyldimethylsilyloxy-2H-pyran-2-one [prepared as described in Example B, above], to give 850 mg of the title compound as a colorless foam.
Sources & evidence
- ORD record
- ord-bc5021a57b1f49588bafe3aaefaec040
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05491167
Reaction notes
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