反应详情

To a stirring solution of ethyl 1-(imidazo[1,2-a]pyrimidine-2-carboxylate (1 g, 5.2 mmol) [Abignente, et al. Eur. J. Med. Chem. (1994) 29, 279] in ethanol (30 mL) was added 2 N aqueous KOH (10 mL, 20 mmol). The solution was heated to reflux; and after 2 h, the heating mantle was removed, the solution was allowed to cool and the solvent was removed by rotary evaporation. The residue was dissolved in water (20 mL) and acidified to pH 3 with 5 N HCl. The resulting precipitate was filtered, washed with water and dried in vacuo to give 700 mg (83%) of a tan solid.

1. temperatureThe solution was heated to reflux
2. customthe heating mantle was removed
3. temperatureto cool
4. customthe solvent was removed by rotary evaporation
5. dissolutionThe residue was dissolved in water (20 mL)
6. filtrationThe resulting precipitate was filtered
7. washwashed with water
8. customdried in vacuo