Pravastatin Diol Lactone Di-(tert-butyldimethylsilyl) Ether → HCID 54474221, compound

Participants

Reaction Steps

A procedure similar to that described in Example 10, above, was followed, but using 875 mg of 2-ethoxy-2-ethylbutyric acid and 1.0 g of (4R,6R)-6-{(1S,2S,6S,8S,8aR)-2-[1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl}tetrahydro-4-t-butyldimethylsilyloxy-2H-pyran-2-one [prepared as described in Example B, above], to give 271 mg of the title compound as a colorless foam.

Provenance & Evidence