2-(4-tert-butylphenoxy)-2-methylpropanoic acid → HCID 54283458, compound

HRID 2396252Notes

Reaction equation

[C:1]([C:5]1[CH:17]=[CH:16][C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Si:18]([O:25][C@H:26]1[CH2:35][C@H:34]([OH:36])[C@H:33]2[C:28]([CH:29]=[CH:30][C@H:31]([CH3:54])[C@@H:32]2[CH2:37][CH2:38][C@H:39]2[O:44][C:43](=[O:45])[CH:42](O[SiH3])[C@H:41](C(C)(C)C)[C:40]2(C)C)=[CH:27]1)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]>>[Si:18]([O:25][C@H:26]1[CH2:35][C@H:34]([O:36][C:11](=[O:13])[C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:17][CH:16]=2)([CH3:15])[CH3:14])[C@H:33]2[C:28]([CH:29]=[CH:30][C@H:31]([CH3:54])[C@@H:32]2[CH2:37][CH2:38][C@H:39]2[O:44][C:43](=[O:45])[CH2:42][C@H:41]([O:25][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])[CH2:40]2)=[CH:27]1)([C:21]([CH3:23])([CH3:22])[CH3:24])([CH3:19])[CH3:20]

Participants

Reactant 2

HCID 7371602-(4-tert-butylphenoxy)-2-methylpropanoic acid

HCID 131719259HCID 131719259, compound

Product 1

HCID 54283458HCID 54283458, compoundYield 160.4%

Procedure

A procedure similar to that described in Example 1, above, was followed, but using 858 mg of 2-(4-t-butylphenoxy)-2-methylpropionic acid and 1.0 g of (4R,6R)-6-{(1S,2S,6S,8S,8aR)-2-[1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl}tetrahydro-4-t-butyldimethyl silyloxy-2H-pyran-2-one [prepared as described in Example B, above], to give 1.12 g of the title compound as a colorless foam.

Sources & evidence

ORD record: ord-373cac8847854cfe9203b02442a11142
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05491167

Reaction notes

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