Ethyl pyridine-4-acetate → Ethyl 2-(hydroxyimino)-2-(pyridin-4-yl)acetate

HRID 23963Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:3][CH:2]=1.[OH:13][N:14]=C(C1C=CC=CN=1)C(OCC)=O>>[OH:13][N:14]=[C:7]([C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

Reactant 2

HCID 736321Ethyl pyridine-4-acetate

HCID 135543845Nsc74475

Product 1

HCID 136338642Ethyl 2-(hydroxyimino)-2-(pyridin-4-yl)acetateYield 82%

Procedure

The oxime was prepared in 82% yield from ethyl pyridine-4-acetate using a procedure similar to that described above under Examples 321-324 for the preparation of ethyl hydroxyimino-pyridine-2-acetate.

Sources & evidence

ORD record: ord-d9131de995fd49c3bda1ddd791e19c72
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06855715B1

Reaction notes

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