反应详情

温度

30 °C

5-Amino-2-methylbenzoxazole (7.0 g, 0.05 mole), isopentyl nitrite (20 mL), and furan (230 mL) were combined and heated with stirring at 30° C. in a roundbottom flask equipped with a condenser. After heating for 48 hrs, the reaction mixture was removed from the heat, washed with water, and then evaporated to an oil. Distillation afforded the product (4.0 g, 43% yield), bp 130°-140° C. (0.6 mm). Recrystallization from isopropyl alcohol (14 mL) afforded 3.0 g (32% yield), mp 60° C.

1. temperatureheated
2. customequipped with a condenser
3. temperatureAfter heating for 48 hrs
4. customthe reaction mixture was removed from the heat
5. washwashed with water
6. customevaporated to an oil
7. distillationDistillation