Methadone Hydrochloride → Methadone

HRID 2396431Notes

Reaction equation

HRID 2396431 reaction equation
[CH3:1][CH2:2][C:3]([C:5]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH2:6][CH:7]([N:9]([CH3:11])[CH3:10])[CH3:8])=[O:4].Cl>O>[CH3:1][CH2:2][C:3]([C:5]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH2:6][CH:7]([N:9]([CH3:11])[CH3:10])[CH3:8])=[O:4]

Participants

3

Reactant 1

HCID 14184Methadone Hydrochloride

Product 1

HCID 4095Methadone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methadone (free base) was prepared for step B below by dissolving 10 grams of methadone hydrochloride in 100 mL of warm water at approximately 50° C. and crystallizing the free base out of solution by slowly adding 20 mL of a saturated aqueous potassium carbonate solution, pH 12.2 to the methadone hydrochloride solution with stirring. After crystallization was complete, the methadone crystals were filtered and redissolved in about 75 mL ethanol (ETOH). Following this the methadone was precipitated by the addition of 200 mL of water. The precipitate was filtered and dried in vacuo. The resulting yield of methadone was 8.79 g methadone or approximately 98%.

Workup

  1. customcrystallizing the free base out of solution
  2. additionby slowly adding 20 mL of a saturated aqueous potassium carbonate solution, pH 12.2 to the methadone hydrochloride solution
  3. customAfter crystallization
  4. filtrationthe methadone crystals were filtered
  5. dissolutionredissolved in about 75 mL ethanol (ETOH)
  6. customwas precipitated by the addition of 200 mL of water
  7. filtrationThe precipitate was filtered
  8. customdried in vacuo

Sources & evidence

ORD record
ord-38e990abd3ce4bafab3f9f63b8d8354a
Source dataset
uspto-grants-1996_02
Patent number
US05492841

Reaction notes

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