HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → 2,4-Dichloro-5-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 4-Methylpentane-1,2-diol | HCID 91171 | — |
| Reactant | 1-Bromo-2,4-dichloro-5-fluorobenzene | HCID 11791393 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Catalyst | Tetrabutylphosphonium bromide | HCID 76564 | — |
| Product | 2,4-Dichloro-5-fluorobenzonitrile | HCID 2782753 | — |
Reaction Steps
97.6 g (0.4 mol) of 5-bromo-2,4-dichlorofluorobenzene, 35.8 g (0.4 mol) of copper(I)cyanide, 10.0 g (0.014 mol) of trimethyl(ethoxypolyoxypropyl)ammonium chloride, 5.0 g (0.015 mol) of tetrabutylphosphonium bromide and 5.0 g (0.01 mol) of polyethylene glycol dimethyl ether 500 were introduced together with 20.0 g (0.19 mol) of xylene into a 250 ml 3-neck flask fitted with a reflux condenser and blade stirrer and azeotropically dried at up to 150° C. under reduced pressure. Amount of 2,4-dichloro-5-fluorobenzonitrile formed: after 5 hours: 19 GC area-%. after 26 hours: 75 GC area-%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05492875 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-831c3ffd12e640e58d374f798b199218 |
| Source note | uspto-grants-1996_02 |