Benzylamine → HCID 18982043, compound

HRID 2396484Notes

Reaction equation

HRID 2396484 reaction equation
[CH2:1]([N:8]([CH3:12])[CH2:9][CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[CH2:1]([N:8]([CH3:12])[CH2:9][CH2:10][NH:20][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 31968N-benzyl-2-chloro-N-methylethanamine

Product 1

HCID 18982043HCID 18982043, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

128 g (0.7 mol) of the compound obtained in Step b dissolved in 600 ml of ethanol are added dropwise to 150 g ( 1.4 mol) of benzylamine diluted in 200 ml of warm ethanol. The mixture is stirred at room temperature for 24 hours and the solvent is evaporated off in vacuo. Benzylamine hydrochloride crystallises from a mixture of methylene chloride and acetone, and is removed by filtration. The tiltrates are saturated with gaseous hydrogen chloride and the hydrochloride of the desired compound crystallises from a methylene chloride/ether mixture. 105 g of white crystals are obtained.

Workup

  1. customthe solvent is evaporated off in vacuo
  2. customBenzylamine hydrochloride crystallises from a mixture of methylene chloride and acetone
  3. customis removed by filtration
  4. customthe hydrochloride of the desired compound crystallises from a methylene chloride/ether mixture

Sources & evidence

ORD record
ord-da0894e9eef34965b6d36a68e0d8d687
Source dataset
uspto-grants-1996_02
Patent number
US05492912

Reaction notes

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