Tetrahydrofuran → HCID 18987439, compound

Participants

Reaction Conditions

Reaction Steps

1-Ethylindole-3-ylcarboxamide oxime (200 mg, 0.98 mmol, prepared by the general method of EP-A-328200) was dissolved in anhydrous THF (4 ml) containing 4-A° powdered molecular sieves (300 mg). The mixture was stirred for 30 mins., sodium hydride (80% dispersion in oil) (40 mg, 1.3 mmol) was added and the mixture was heated at 60° C. for 20 min. It was then cooled to RT and a solution of methyl-4-piperidinyl butyrate (364 mg, 1.98 mmol) in THF (2 mol) was added. The resulting mixture was heated at reflux for 1 hr., cooled, filtered and the filtrate concentrated under vacuum. The residue was purified by column chromatography to give the product (210 mg).

Provenance & Evidence