反应详情

3-(1-Methyl-1H-indol-3-yl)-1,2,4-triazole (0.190 g, 0.960 mmol) was dissolved with stirring in dry THF (5 ml) and was treated with sodium hydride (80%) (0.032 g, 1.05 mmol), followed by 1-(bromoacetyl)piperidine (Bull. Soc, Chim. Fr. 1964, 5, 1063-9) (0.232 g, 1.05 mmol) in dry THF (1 ml). After 4 h, the reaction mixture was evaporated under reduced pressure and partitioned between EtOAc and water. The organic layer was then dried (Na2SO4) and evaporated under reduced pressure to give a yellow oil, which was purified by silica-gel chromatography (EtOAc→EtOAc:MeOH 100:1 as eluant) to give the title compound (D5b) as a white solid (0.080 g, 26%).

1. customthe reaction mixture was evaporated under reduced pressure
2. custompartitioned between EtOAc and water
3. dry with materialThe organic layer was then dried (Na2SO4)
4. customevaporated under reduced pressure
5. customto give a yellow oil, which
6. customwas purified by silica-gel chromatography (EtOAc→EtOAc:MeOH 100:1 as eluant)