Acrolein → Ethyl 2-chloro-2-cyano-5-oxopentanoate

Participants

Reaction Conditions

Reaction Steps

To a suspension of NaOAc (0.492 g, 6 mmol) in 200 mL of EtOAc were added at 5° C., 31.0 g (210 mmol) of ethyl chlorocyanoacetate and acrolein (14 g, 250 mmol). The resulting mixture was stirred at 35° C. for 16 hours, filtered, concentrated and distilled to give 33 g of the title compound (77%).

Provenance & Evidence