HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-Amino-2-chloro-4-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Chloro-3-pyridylamine | HCID 80528 | — |
| Reactant | 2-Chloro-4-methylpyridine-3-carboxamide | HCID 10942886 | — |
| Product | 3-Amino-2-chloro-4-methylpyridine | HCID 2756387 | 90% |
Reaction Steps
In a manner similar to that described for 2-chloro-3-aminopyridine in Example 14, the title compound was prepared in 90% yield (m.p. 63°-66° C., uncorrected) from 2.57 g of 2-chloro-4-methyl-3-pyridinecarboxamide, 2.28 g of NaOH, and 3.1 g of bromine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05493028 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-dc49db542cfc4b73ad2b4ed7f83843e0 |
| Source note | uspto-grants-1996_02 |