HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl cyanoacetate → Ethyl 2-chloro-2-cyano-3-methyl-5-oxopentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Crotonaldehyde | HCID 447466 | — |
| Reactant | Ethyl dichlorocyanoacetate | HCID 10997655 | — |
| Reactant | Ethyl 2-chloro-2-cyano-5-oxopentanoate | HCID 10998104 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 2-chloro-2-cyano-3-methyl-5-oxopentanoate | HCID 10867727 | 34% |
Reaction Steps
Following the procedure for the preparation of ethyl 2-chloro-2-cyano-5-oxopentanoate (Example 1), 37.6 g of ethyl cyanoacetate, 60.5 g of ethyl dichlorocyanoacetate, 350 mL of EtOAc, 1.7 g of K2CO3, and 56 mL of crotonaldehyde were allowed to react for an extended period of time. The title compound was obtained in 34% yield after workup and distillation (b.p. 115° C./1.0 mm Hg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05493028 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-e3a2ecc3c362403daf7dfc0786a1dddf |
| Source note | uspto-grants-1996_02 |