HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-Chloro-4-methylpyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Chloronicotinamide | HCID 82588 | — |
| Reactant | Ethyl 2-chloro-4-methylnicotinate | HCID 11769512 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-Chloro-4-methylpyridine-3-carboxamide | HCID 10942886 | 64% |
Reaction Steps
In a manner similar to that described for 2-chloro-3-pyridinecarboxamide in Example 13, the title compound (m.p. 168-170) was prepared in 64% yield from 4 g of ethyl 2-chloro-4-methyl-3-pyridinecarboxylate, 1 g of NH4Cl, 30 mL of concentrated aqueous ammonia, and 0.6 of Bu4NBr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05493028 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-238cbb26a9994d04abb5a03391bf38d9 |
| Source note | uspto-grants-1996_02 |