HCID 10069108, compound → HCID 131719264, compound

HRID 2396627Notes

Reaction equation

HRID 2396627 reaction equation
[Si:1]([O:8][C:9]1[C:17]([CH2:18][CH:19](O)[C:20]([CH3:22])=[CH2:21])=[C:16]([O:24][CH3:25])[C:15]([CH3:26])=[C:14]2[C:10]=1[C:11](=[O:27])[O:12][CH2:13]2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>C(OC)(OC)(OC)CC.C(O)(=O)CC>[Si:1]([O:8][C:9]1[C:17]([CH2:18]/[CH:19]=[C:20](\[CH3:22])/[CH2:21][CH:10]([CH3:9])[C:11]([O:12][CH3:13])=[O:27])=[C:16]([O:24][CH3:25])[C:15]([CH3:26])=[C:14]2[C:10]=1[C:11](=[O:27])[O:12][CH2:13]2)([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 10069108HCID 10069108, compound

Product 1

HCID 131719264HCID 131719264, compound

Reagents, catalysts & solvents 2

HCID 1032Propionic AcidSolventHCID 1411451,1,1-TrimethoxypropaneSolvent

Procedure

A solution of 4-(4-tert-butyldimethylsilyloxy-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-3-hydroxy-2-methylbut-1-ene (0.91 g) in trimethyl orthopropionate (25 ml) and propionic acid (0.08 ml) was heated to 110° C. for 2.5 hours. The solvents were evaporated under vacuum to afford methyl (E) 6-(4-tert-butyldimethylsilyloxy-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-2,4-dimethyl-4-hexenoate as an oil.

Workup

  1. customThe solvents were evaporated under vacuum

Sources & evidence

ORD record
ord-e03b1eb72a9c45b297915664a2fc8302
Source dataset
uspto-grants-1996_02
Patent number
US05493030

Reaction notes

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