HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 178506026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-(3-Fluoropropyl)propane-1,3-diol | HCID 14985208 | — |
| Reactant | 3',4'-Difluoro[1,1'-biphenyl]-4-carbaldehyde | HCID 15180850 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178506026 | HCID 178506026 | — |
Reaction Steps
A mixture of 0.1 m of 2-(3-fluoropropyl)-1,3-propanediol, 0.1 m of p-(3,4-difluorophenyl)benzaldehyde (prepared by cross-coupling as described above), 1 g of p-toluenesulfonic acid and 200 ml of toluene is boiled for 1 hour on a water separator. Extractive work-up and purification by crystallization and chromatography give trans-2-(3,4-difluorobiphenyl-4'-yl)-5-(3-fluoropropyl)-1,3-dioxane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05494606 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-470f5a908ba441678ea0e0923580f26f |
| Source note | uspto-grants-1996_02 |