Methanol → HCID 178503526, compound

Participants

Reaction Steps

A mixture of 22.1 g (0.123 mot) of 4-hydroxypyrido[3,2-d]pyrimidine-2-thiol, 65 mL of 25 percent sodium methoxide in methanol (0.28 mol), 8.9 mL (20.1 g, 0.142 mol) of methyl iodide, and 500 mL of methanol was prepared and allowed to react at ambient temperature with stirring until the starting material thiol disappeared as determined by high pressure liquid chromatography (HPLC). The mixture was then acidified with acetic acid and the volatile components were removed by evaporation under reduced pressure. The residue was diluted with water and the solids were recovered by filtration, washed with ether, and dried overnight in a vacuum oven. The resultant white powder was the title compound melting at 229°-231° C.

Provenance & Evidence