HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2396707Generated: November 1, 2026
Methyl(2-(morpholin-4-yl)ethyl)amine → 6-Methoxy-N-methyl-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine
https://huagongshe.com/reaction/2396707
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl(2-(morpholin-4-yl)ethyl)amine | HCID 14979282 | — |
| Reactant | 3-Chloro-6-methoxy-1,2-benzoxazole | HCID 15816924 | — |
| Product | 6-Methoxy-N-methyl-N-[2-(4-morpholinyl)ethyl]-1,2-benzisoxazol-3-amine | HCID 15816925 | 49.4% |
Reaction Steps
To a sealed tube was added 3-chloro-6-methoxy-1,2-benzisoxazole (6.0 g) and N-methyl-N-[2-(4-morpholinyl)ethyl]-amine (13.8 g). The reaction was heated to 140° C. over 48 hours and then cooled to room temperature. The residue was partitioned between ethyl acetate (EtOAc) and water, extracted again with EtOAc, and the organic phase was dried over magnesium sulfate (MgSO4) and concentrated in vacuo. Flash column chromatography (silica gel) eluting with 1% methanol/dichloromethane (MeOH/DCM) provided the product (4.7 g), m.p. 43°-44° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05494908 |
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| Source dataset | uspto-grants-1996_02 |
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| ORD ID | ord-8966ff6b58df472f9ee88684e7beec7d |
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| Source note | uspto-grants-1996_02 |
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