HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2396733Generated: October 29, 2026
1-(2-Pyridyl)piperazine → 6-Methoxy-3-[1-(2-pyridyl)piperazinyl]-1,2-benzisoxazole
https://huagongshe.com/reaction/2396733
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Reactant | 3-Chloro-6-methoxy-1,2-benzoxazole | HCID 15816924 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methoxy-3-[1-(2-pyridyl)piperazinyl]-1,2-benzisoxazole | HCID 53702907 | 34.5% |
Reaction Steps
A sealed tube was charged with 3-chloro-6-methoxy-1,2-benzisoxazole (0.25 g, 1.4mmol) and 1-(2-pyridyl)piperazine (0.67 g, 4 mmol) and heated to 140° C. overnight. The reaction was cooled to room temperature, diluted with methanol, and concentrated in vacuo. The material was flash chromatographed (silica gel) eluting with CH2Cl2. The material was further purified through recrystallization from 1,2-dichloroethane/pet. ether to afford 0.15 g of the product, m.p.=123°-124° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05494908 |
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| Source dataset | uspto-grants-1996_02 |
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| ORD ID | ord-af5a1197ccb344068d4da4f081ed5315 |
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| Source note | uspto-grants-1996_02 |
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