1-Acetyl-5-fluoro-1H-indol-3-yl acetate → 1-Acetyl-5-fluoro-1,2-dihydro-3H-indol-3-one

Participants

Reaction Steps

2.2 g of 3-acetoxy-1-acetyl-5-fluoroindole were added to 20 ml of 90% sulfuric acid and, after stirring for three quarters of an hour, the reaction mixture was diluted with 100 ml of ice-water. The precipitate was filtered off, washed with water and dried. There were obtained 1.6 g (83%) of 1-acetyl-5-fluoroindolin-3-one as beige crystals with a m.p. of 143°-144°.

Provenance & Evidence