Fumaric Acid → HCID 67737577, compound

Participants

Reaction Steps

A suspension of 0.1 g of platinum oxide in 25 ml of ethanol was stirred under a hydrogen atmosphere for half an hour and subsequently treated with a solution of 0.92 g of (R)-1-(2-azido-propyl)-5-fluoroindole in 25 ml of ethanol. The reaction mixture was stirred at room temperature for two hours. The catalyst was filtered off and washed with ethanol. The solution was evaporated and the residue was dissolved in 150 ml of ether and treated with 0.58 g (5 mmol) of fumaric acid and stirred overnight. The separated crystals were filtered off and dried. There were obtained 1.14 g (88%) of (R)-2-(5-fluoro-indol-1-yl)-1-methyl-ethylamine fumarate (1:1) as white crystals with m.p. 159°-161° (dec.)

Provenance & Evidence