Sodium Hydroxide → HCID 18986211, compound

HRID 2396844Notes

Reaction equation

HRID 2396844 reaction equation
[F:1][C:2]1[C:3]([C:16]([F:19])([F:18])[F:17])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13]CC)=[O:12])=[CH:5]2.[OH-].[Na+]>C(O)C>[F:1][C:2]1[C:3]([C:16]([F:18])([F:17])[F:19])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=[O:12])=[CH:5]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18986276HCID 18986276, compound

Product 1

HCID 18986211HCID 18986211, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.24 g of ethyl 5-fluoro-4-trifluoromethylindole-2-carboxylate in 80 ml of ethanol was treated with 40 ml of 2N sodium hydroxide solution and stirred at room temperature for 1 hour. The alcohol was evaporated and the solution was adjusted to pH 1 with 2N hydrochloric acid. The separated crystals were isolated, washed with water and dried. There were obtained 1.17 g (85%) of 5-fluoro-4-trifluoromethylindole-2-carboxylic acid as beige crystals with m.p. 204°-210°.

Workup

  1. customThe alcohol was evaporated
  2. customThe separated crystals were isolated
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-e2763ec2762e48f8b569ec33d9ad345b
Source dataset
uspto-grants-1996_02
Patent number
US05494928

Reaction notes

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